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Combination of guanine arabinoside and Bcl‐2 inhibitor YC137 overcomes the cytarabine resistance in HL‐60 leukemia cell line

Cytarabine (ara‐C) is the key agent for treating acute myeloid leukemia. After being transported into leukemic cells, ara‐C is phosphorylated, by several enzymes including deoxycytidine kinase (dCK), to ara‐C triphosphate (ara‐CTP), an active metabolite, and then incorporated into DNA, thereby inhib...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Nishi, Rie, Yamauchi, Takahiro, Negoro, Eiju, Takemura, Haruyuki, Ueda, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657161/
https://ncbi.nlm.nih.gov/pubmed/23320492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12103
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