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Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

BACKGROUND: Cytarabine (ara-C) is the major drug for the treatment of acute myeloid leukemia (AML), but cellular resistance to ara-C is a major obstacle to therapeutic success. The present study examined enhanced anti-apoptosis identified in 3 newly established nucleoside analogue-resistant leukemic...

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Publicado en:BMC Cancer
Autores principales: Nishi, Rie, Shigemi, Hiroko, Negoro, Eiju, Okura, Miyuki, Hosono, Naoko, Yamauchi, Takahiro
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552348/
https://ncbi.nlm.nih.gov/pubmed/33046037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07469-x
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