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Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation

Aging leads to functional decline of the hematopoietic system, manifested by an increased incidence of hematological disease in the elderly. Deterioration of hematopoietic integrity with age originates in part from the degraded functionality of hematopoietic stem cells (HSCs). Here, we review recent...

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Bibliographic Details
Published in:Trends Mol Med
Main Authors: Verovskaya, Evgenia V., Dellorusso, Paul V., Passegué, Emmanuelle
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657013/
https://ncbi.nlm.nih.gov/pubmed/31109796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2019.04.006
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