Stromal niche inflammation mediated by IL-1 signaling is a targetable driver of hematopoietic aging

Hematopoietic aging is marked by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells (HSC) leading to impaired blood production. Signals from the bone marrow (BM) niche tailor blood production, but the contribution of the old niche to hematopoietic aging remains...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Cell Biol
Prif Awduron: Mitchell, Carl A., Verovskaya, Evgenia V., Calero-Nieto, Fernando J., Olson, Oakley C., Swann, James W., Wang, Xiaonan, Hérault, Aurélie, Dellorusso, Paul V., Zhang, Si Yi, Svendsen, Arthur Flohr, Pietras, Eric M., Bakker, Sietske T., Ho, Theodore T., Göttgens, Berthold, Passegué, Emmanuelle
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2023
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614279/
https://ncbi.nlm.nih.gov/pubmed/36650381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-022-01053-0
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