FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia

Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism’s lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated with systemic metabolic disorders is poorly understood...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Govindarajah, Vinothini, Lee, Jung-Mi, Solomon, Michael, Goddard, Bryan, Nayak, Ramesh, Nattamai, Kalpana, Geiger, Hartmut, Salomonis, Nathan, Cancelas, Jose A., Reynaud, Damien
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656925/
https://ncbi.nlm.nih.gov/pubmed/33166407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001826
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