FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia

Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism’s lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated with systemic metabolic disorders is poorly understood...

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Detalles Bibliográficos
Publicado en:Blood Adv
Main Authors: Govindarajah, Vinothini, Lee, Jung-Mi, Solomon, Michael, Goddard, Bryan, Nayak, Ramesh, Nattamai, Kalpana, Geiger, Hartmut, Salomonis, Nathan, Cancelas, Jose A., Reynaud, Damien
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656925/
https://ncbi.nlm.nih.gov/pubmed/33166407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001826
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