Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression

Obesity is a chronic organismal stress that disrupts multiple systemic and tissue-specific functions. In this study, we describe the impact of obesity on the activity of the hematopoietic stem cell (HSC) compartment. We show that obesity alters the composition of the HSC compartment and its activity...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Lee, Jung-Mi, Govindarajah, Vinothini, Goddard, Bryan, Hinge, Ashwini, Muench, David E., Filippi, Marie-Dominique, Aronow, Bruce, Cancelas, Jose A., Salomonis, Nathan, Grimes, H. Leighton, Reynaud, Damien
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789409/
https://ncbi.nlm.nih.gov/pubmed/29282250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170690
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