Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

The metabolic requirements of hematopoietic stem cell (HSC) change with their cell cycle activity. However, the underlying role of mitochondria remain ill-defined. Here, we found that after mitochondrial activation with replication, HSC irreversibly remodel the mitochondrial network and this network...

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Bibliografiska uppgifter
I publikationen:Cell Stem Cell
Huvudupphovsmän: Hinge, Ashwini, He, Jingyi, Bartram, James, Javier, Jose, Xu, Juying, Fjellman, Ellen, Sesaki, Hiromi, Li, Tingyu, Yu, Jie, Wunderlich, Mark, Mulloy, James, Kofron, Matthew, Salomonis, Nathan, Grimes, H. Leighton, Filippi, Marie-Dominique
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212526/
https://ncbi.nlm.nih.gov/pubmed/32059807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.01.016
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