Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

The metabolic requirements of hematopoietic stem cell (HSC) change with their cell cycle activity. However, the underlying role of mitochondria remain ill-defined. Here, we found that after mitochondrial activation with replication, HSC irreversibly remodel the mitochondrial network and this network...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Hinge, Ashwini, He, Jingyi, Bartram, James, Javier, Jose, Xu, Juying, Fjellman, Ellen, Sesaki, Hiromi, Li, Tingyu, Yu, Jie, Wunderlich, Mark, Mulloy, James, Kofron, Matthew, Salomonis, Nathan, Grimes, H. Leighton, Filippi, Marie-Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212526/
https://ncbi.nlm.nih.gov/pubmed/32059807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.01.016
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