FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia

Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism’s lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated with systemic metabolic disorders is poorly understood...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Govindarajah, Vinothini, Lee, Jung-Mi, Solomon, Michael, Goddard, Bryan, Nayak, Ramesh, Nattamai, Kalpana, Geiger, Hartmut, Salomonis, Nathan, Cancelas, Jose A., Reynaud, Damien
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656925/
https://ncbi.nlm.nih.gov/pubmed/33166407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001826
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