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Aged murine hematopoietic stem cells drive aging-associated immune remodeling

Aging-associated remodeling of the immune system impairs its functional integrity and contributes to increased morbidity and mortality in the elderly. Aging of hematopoietic stem cells (HSCs), from which all cells of the adaptive immune system ultimately originate, might play a crucial role in the r...

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Publicado en:Blood
Autores principales: Leins, Hanna, Mulaw, Medhanie, Eiwen, Karina, Sakk, Vadim, Liang, Ying, Denkinger, Michael, Geiger, Hartmut, Schirmbeck, Reinhold
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137572/
https://ncbi.nlm.nih.gov/pubmed/29891535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-02-831065
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