Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer’s disease

Alzheimer’s disease (AD) is characterised by abnormal amyloid beta and tau processing. Previous studies reported that cerebrospinal fluid (CSF) total tau (t-tau) levels vary between patients. Here we show that CSF t-tau variability is associated with distinct impairments in neuronal plasticity media...

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Detalhes bibliográficos
Publicado no:medRxiv
Main Authors: Visser, Pieter Jelle, Reus, Lianne M., Gobom, Johan, Jansen, Iris, Dicks, Ellen, Tsolaki, Magda, Verhey, Frans R.J., Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Molinuevo, José Luís, Engelborghs, Sebastiaan, Freund-Levi, Yvonne, Froelich, Lutz, Sleegers, Kristel, Dobricic, Valerija, Hong, Shengjun, Lovestone, Simon, Streffer, Johannes, Vos, Stephanie J.B., Bos, Isabelle, Smit, August B., Blennow, Kaj, Scheltens, Philip, Teunissen, Charlotte E., Bertram, Lars, Zetterberg, Henrik, Tijms, Betty M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654872/
https://ncbi.nlm.nih.gov/pubmed/33173883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.29.20211920
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