APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

Abstract Background Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer’s disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ε4 genotype plays a major role. We aimed to identify the mo...

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Main Authors: Elles Konijnenberg, Betty M. Tijms, Johan Gobom, Valerija Dobricic, Isabelle Bos, Stephanie Vos, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, Lutz Frölich, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Charlotte E. Teunissen, Robert Veerhuis, August B. Smit, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visser
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-05-01
Serier:Alzheimer’s Research & Therapy
Fag:
Amyloid aggregation
APOE genotype
CSF proteomics
Online adgang:http://link.springer.com/article/10.1186/s13195-020-00628-z
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