APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

BACKGROUND: Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer’s disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ε4 genotype plays a major role. We aimed to identify the molecular...

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Détails bibliographiques
Publié dans:Alzheimers Res Ther
Auteurs principaux: Konijnenberg, Elles, Tijms, Betty M., Gobom, Johan, Dobricic, Valerija, Bos, Isabelle, Vos, Stephanie, Tsolaki, Magda, Verhey, Frans, Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Frölich, Lutz, Lovestone, Simon, Streffer, Johannes, Bertram, Lars, Blennow, Kaj, Teunissen, Charlotte E., Veerhuis, Robert, Smit, August B., Scheltens, Philip, Zetterberg, Henrik, Visser, Pieter Jelle
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254647/
https://ncbi.nlm.nih.gov/pubmed/32460813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00628-z
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