Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer’s disease

Alzheimer’s disease (AD) is characterised by abnormal amyloid beta and tau processing. Previous studies reported that cerebrospinal fluid (CSF) total tau (t-tau) levels vary between patients. Here we show that CSF t-tau variability is associated with distinct impairments in neuronal plasticity media...

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Publicat a:medRxiv
Autors principals: Visser, Pieter Jelle, Reus, Lianne M., Gobom, Johan, Jansen, Iris, Dicks, Ellen, Tsolaki, Magda, Verhey, Frans R.J., Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Molinuevo, José Luís, Engelborghs, Sebastiaan, Freund-Levi, Yvonne, Froelich, Lutz, Sleegers, Kristel, Dobricic, Valerija, Hong, Shengjun, Lovestone, Simon, Streffer, Johannes, Vos, Stephanie J.B., Bos, Isabelle, Smit, August B., Blennow, Kaj, Scheltens, Philip, Teunissen, Charlotte E., Bertram, Lars, Zetterberg, Henrik, Tijms, Betty M.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654872/
https://ncbi.nlm.nih.gov/pubmed/33173883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.29.20211920
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