The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites

In response to cholesterol deprivation, SCAP escorts SREBP transcription factors from the endoplasmic reticulum to the Golgi complex for their proteolytic activation, leading to gene expression for cholesterol synthesis and uptake. Here, we show that in cholesterol-fed cells, ER-localized SCAP inter...

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Dades bibliogràfiques
Publicat a:J Cell Biol
Autors principals: Wakana, Yuichi, Hayashi, Kaito, Nemoto, Takumi, Watanabe, Chiaki, Taoka, Masato, Angulo-Capel, Jessica, Garcia-Parajo, Maria F., Kumata, Hidetoshi, Umemura, Tomonari, Inoue, Hiroki, Arasaki, Kohei, Campelo, Felix, Tagaya, Mitsuo
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654440/
https://ncbi.nlm.nih.gov/pubmed/33156328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202002150
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