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The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites
In response to cholesterol deprivation, SCAP escorts SREBP transcription factors from the endoplasmic reticulum to the Golgi complex for their proteolytic activation, leading to gene expression for cholesterol synthesis and uptake. Here, we show that in cholesterol-fed cells, ER-localized SCAP inter...
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| Veröffentlicht in: | J Cell Biol |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Rockefeller University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7654440/ https://ncbi.nlm.nih.gov/pubmed/33156328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202002150 |
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