The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites

In response to cholesterol deprivation, SCAP escorts SREBP transcription factors from the endoplasmic reticulum to the Golgi complex for their proteolytic activation, leading to gene expression for cholesterol synthesis and uptake. Here, we show that in cholesterol-fed cells, ER-localized SCAP inter...

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Publicado en:J Cell Biol
Autores principales: Wakana, Yuichi, Hayashi, Kaito, Nemoto, Takumi, Watanabe, Chiaki, Taoka, Masato, Angulo-Capel, Jessica, Garcia-Parajo, Maria F., Kumata, Hidetoshi, Umemura, Tomonari, Inoue, Hiroki, Arasaki, Kohei, Campelo, Felix, Tagaya, Mitsuo
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654440/
https://ncbi.nlm.nih.gov/pubmed/33156328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202002150
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