The mRNA m(6)A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

The mRNA N(6)-methyladenosine (m(6)A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m(6)A mRNA reader YTHDF2, which recognizes m(6)A-modified transcripts to promote m(6)A-mRNA degradation, results in hematopoietic stem cell (HSC) expans...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Mapperley, Christopher, van de Lagemaat, Louie N., Lawson, Hannah, Tavosanis, Andrea, Paris, Jasmin, Campos, Joana, Wotherspoon, David, Durko, Jozef, Sarapuu, Annika, Choe, Junho, Ivanova, Ivayla, Krause, Daniela S., von Kriegsheim, Alex, Much, Christian, Morgan, Marcos, Gregory, Richard I., Mead, Adam J., O’Carroll, Dónal, Kranc, Kamil R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2020
Soggetti:
Brief Definitive Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653684/
https://ncbi.nlm.nih.gov/pubmed/33156926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200829
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