The RNA m(6)A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence

YTHDF2 binds and destabilizes N(6)-methyladenosine (m(6)A)-modified mRNA. The extent to which this branch of m(6)A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown. Here we find that YTHDF2 deficiency is partially permissive in mice and results in fem...

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Vydáno v:Mol Cell
Hlavní autoři: Ivanova, Ivayla, Much, Christian, Di Giacomo, Monica, Azzi, Chiara, Morgan, Marcos, Moreira, Pedro N., Monahan, Jack, Carrieri, Claudia, Enright, Anton J., O’Carroll, Dónal
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
Témata:
Short Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613143/
https://ncbi.nlm.nih.gov/pubmed/28867294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.08.003
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