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The mRNA m(6)A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

The mRNA N(6)-methyladenosine (m(6)A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m(6)A mRNA reader YTHDF2, which recognizes m(6)A-modified transcripts to promote m(6)A-mRNA degradation, results in hematopoietic stem cell (HSC) expans...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Mapperley, Christopher, van de Lagemaat, Louie N., Lawson, Hannah, Tavosanis, Andrea, Paris, Jasmin, Campos, Joana, Wotherspoon, David, Durko, Jozef, Sarapuu, Annika, Choe, Junho, Ivanova, Ivayla, Krause, Daniela S., von Kriegsheim, Alex, Much, Christian, Morgan, Marcos, Gregory, Richard I., Mead, Adam J., O’Carroll, Dónal, Kranc, Kamil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653684/
https://ncbi.nlm.nih.gov/pubmed/33156926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200829
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