TAMI-33. AURKA INHIBITION REPROGRAMS METABOLISM AND IS SYNTHETICALLY LETHAL WITH FATTY ACID OXIDATION INHIBITION IN GLIOBLASTOMA

Aurora kinase A (AURKA) has emerged as a viable drug target for glioblastoma (GBM), the most common malignant primary brain tumor in adults with a life expectancy of 12-15 months. However, resistance to therapy remains a critical issue, which partially may be driven by reprogramming of metabolism. B...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Nguyen, Trang, Shang, Enyuan, Shu, Chang, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Quinzii, Catarina, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey, Canoll, Peter, Siegelin, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651513/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.921
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