EXTH-70. CYP450 AND METABOLIC PROFILING OF ANTI-CANCER IMIPRIDONE ONC201

Imipridone ONC201 is an investigational agent in phase II clinical trials for high grade gliomas as a single agent once weekly. Systemic and tumor exposure to ONC201 exceeds therapeutic thresholds consistently; however, exposure is variable despite fasted conditions and does not strongly covary with...

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Vydáno v:Neuro Oncol
Hlavní autoři: Morrow, Sara, Prabhu, Varun, Tarapore, Rohinton S, Guo, Ailan, Fang, Yunlan, Nej, Magdalena, Stogniew, Martin, Allen, Joshua
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Preclinical Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651349/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.424
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