EXTH-77. ONC201 EXHIBITS PASSIVE DIFFUSION AND BROAD DISTRIBUTION IN THE CENTRAL NERVOUS SYSTEM

Imipridone ONC201 is an investigational agent in phase II clinical trials for H3 K27M-mutant diffuse midline glioma with evidence of durable objective responses and clinical symptom improvements as a single agent. The systemic pharmacokinetics of ONC201 and its ability to achieve target concentratio...

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Vydáno v:Neuro Oncol
Hlavní autoři: Morrow, Sara, Prabhu, Varun, Tarapore, Rohinton S, Theerman, Gina, Lake, Leah, Guo, Ailan, Stogniew, Martin, Allen, Joshua
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Preclinical Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651267/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.431
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