IMMU-55. GD2 IS A MACROPHAGE CHECKPOINT MOLECULE AND COMBINED GD2/CD47 BLOCKADE RESULTS IN SYNERGISTIC EFFECTS AGAINST GD2 POSITIVE MALIGNANCIES

GD2 is a disialoganglioside expressed on a variety of tumors including DIPG, neuroblastoma and osteosarcoma. Anti-GD2 antibodies have demonstrated some success in neuroblastoma and they have either not proven to be effective or have not been evaluated in other GD2 positive malignancies. CD47 is the...

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發表在:Neuro Oncol
Main Authors: Theruvath, Johanna, Mount, Christopher, Monje, Michelle, Mackall, Crystal, Majzner, Robbie
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651266/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.484
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