IMMU-45. CHECKPOINT MOLECULE B7-H3 IS HIGHLY EXPRESSED ON MEDULLOBLASTOMA AND PROVES TO BE A PROMISING CANDIDATE FOR CAR T CELL IMMUNOTHERAPY

BACKGROUND: B7-H3 (CD276) is a member of the B7 family of molecules involved in immune regulation and is over-expressed on a wide variety of solid tumor types. The Mackall group previously created a second-generation chimeric antigen receptor (CAR) T-cell targeting B7-H3 with the 4-1BB using a binde...

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Published in:Neuro Oncol
Main Authors: Theruvath, Johanna, Heitzeneder, Sabine, Majzner, Robbie, Cui, Karen, Nellan, Anandani, Graef, Claus Moritz, Cheshier, Samuel H, Mackall, Crystal, Mitra, Siddhartha S
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692740/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.503
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