IMMU-07. CHECKPOINT MOLECULE B7-H3 IS HIGHLY EXPRESSED ON MEDULLOBLASTOMA AND PROVES TO BE A PROMISING CANDIDATE FOR CAR T CELL IMMUNOTHERAPY

BACKGROUND: B7-H3 (CD276) is a member of the B7 family of molecules involved in immune regulation and is over-expressed on a wide variety of solid tumor types. For this study we used a second-generation chimeric antigen receptor (CAR) T-cell targeting B7-H3 with the 41BB using a binder based on anti...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Theruvath, Johanna, Heitzeneder, Sabine, Majzner, Robbie, Moritz Graef, Claus, Cui, Karen, Nellan, Anandani, H Cheshier, Samuel, Mackall, Crystal, Mitra, Siddhartha
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475088/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.117
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