EXTH-20. SYNGENEIC B7-H3-SPECIFIC CAR T-CELLS HAVE POTENT ANTI-BRAIN TUMOR ACTIVITY VIA LOCAL OR SYSTEMIC DELIVERY

BACKGROUND: We and others have identified B7-H3 (CD276) as a promising target for CAR T-cell-based immunotherapies for pediatric brain tumors. So far, B7-H3-CAR T cells have only been studied in xenograft models for brain tumors, which do not recapitulate the immunosuppressive tumor microenvironment...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Haydar, Dalia, Yi, Zhongzhen, Houke, Haley, Roussel, Martine F, DeRenzo, Chris, Gottschalk, Stephen, Krenciute, Giedre
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Preclinical Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651149/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.374
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares