Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery

BACKGROUND: Immunotherapy with chimeric antigen receptor (CAR) T cells is actively being explored for pediatric brain tumors in preclinical models and early phase clinical studies. At present, it is unclear which CAR target antigens are consistently expressed across different pediatric brain tumor t...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Haydar, Dalia, Houke, Haley, Chiang, Jason, Yi, Zhongzhen, Odé, Zelda, Caldwell, Kenneth, Zhu, Xiaoyan, Mercer, Kimberly S, Stripay, Jennifer L, Shaw, Timothy I, Vogel, Peter, DeRenzo, Christopher, Baker, Suzanne J, Roussel, Martine F, Gottschalk, Stephen, Krenciute, Giedre
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168826/
https://ncbi.nlm.nih.gov/pubmed/33320196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa278
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