Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery

BACKGROUND: Immunotherapy with chimeric antigen receptor (CAR) T cells is actively being explored for pediatric brain tumors in preclinical models and early phase clinical studies. At present, it is unclear which CAR target antigens are consistently expressed across different pediatric brain tumor t...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Haydar, Dalia, Houke, Haley, Chiang, Jason, Yi, Zhongzhen, Odé, Zelda, Caldwell, Kenneth, Zhu, Xiaoyan, Mercer, Kimberly S, Stripay, Jennifer L, Shaw, Timothy I, Vogel, Peter, DeRenzo, Christopher, Baker, Suzanne J, Roussel, Martine F, Gottschalk, Stephen, Krenciute, Giedre
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168826/
https://ncbi.nlm.nih.gov/pubmed/33320196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa278
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