EXTH-73. HETEROGENEITY IN CELL SURFACE ANTIGEN AND HLA CLASS I EXPRESSION IN PEDIATRIC BRAIN TUMORS AND ITS IMPACT ON T-CELL IMMUNOTHERAPY

Immunotherapy with tumor antigen-specific chimeric antigen receptor (CAR) and/or ab (T-cell receptor) TCR T-cells has the potential to improve clinical outcomes of patients with pediatric brain tumors. As a prerequisite for successful T-cell therapies, we must determine which cell surface antigens a...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Houke, Haley, Zhu, Xiaoyan, Mercer, Kimberly S, Stripay, Jennifer L, Chiang, Jason, Baker, Suzanne, Roussel, Martine F, Gottschalk, Stephen, Krenciute, Giedre
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Preclinical Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651699/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.427
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