Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery

BACKGROUND: Immunotherapy with chimeric antigen receptor (CAR) T cells is actively being explored for pediatric brain tumors in preclinical models and early phase clinical studies. At present, it is unclear which CAR target antigens are consistently expressed across different pediatric brain tumor t...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Haydar, Dalia, Houke, Haley, Chiang, Jason, Yi, Zhongzhen, Odé, Zelda, Caldwell, Kenneth, Zhu, Xiaoyan, Mercer, Kimberly S, Stripay, Jennifer L, Shaw, Timothy I, Vogel, Peter, DeRenzo, Christopher, Baker, Suzanne J, Roussel, Martine F, Gottschalk, Stephen, Krenciute, Giedre
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168826/
https://ncbi.nlm.nih.gov/pubmed/33320196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa278
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