BIOM-26. MOLECULAR PREDICTORS OF RESPONSE TO SELINEXOR IN RECURRENT GLIOBLASTOMA (GBM)

The nuclear export protein exportin 1 (XPO1) is overexpressed in many cancers, including GBM. Selinexor is an inhibitor of XPO1 that crosses the blood-brain-barrier and targets cancer cells by sequestering tumor suppressor proteins and oncoprotein mRNAs in the nucleus, inducing cancer cell apoptosis...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Walker, Christopher, Shen, Yao, Mau-Soerensen, Morten, Wen, Patrick, van den Bent, Martin, Plotkin, Scott, Walenkamp, Annemiek, Green, Adam, Califano, Andrea, Chang, Hua, Tamir, Sharon, Henegar, Leah, Shacham, Sharon, Alvarez, Mariano, Landesman, Yosef, Lassman, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Biomarkers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650493/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.026
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