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OS07.5 Interim analysis data from Phase 2 study on efficacy, safety & intratumoral pharmacokinetics of oral Selinexor (KPT-330) in patients with recurrent glioblastoma (GBM)
Background: The nuclear export protein exportin 1, (XPO1) is overexpressed in a wide variety of cancers. XPO1 overexpression in glioma correlates with higher grade and decreased overall survival. Selinexor (SEL) is an oral selective inhibitor of XPO1 which crosses the blood-brain barrier. SEL forces...
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Publicado no: | Neuro Oncol |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5463646/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.046 |
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