Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the recent global pandemic. The nuclear export protein (XPO1) has a direct role in the export of SARS-CoV proteins including ORF3b, ORF9b, and nucleocapsid. Inh...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antiviral Res
Auteurs principaux: Kashyap, Trinayan, Murray, Jackelyn, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Hou, Bing, Shacham, Sharon, Kauffman, Michael G., Tripp, Ralph A., Landesman, Yosef
Format: Artigo
Langue:Inglês
Publié: The Authors. Published by Elsevier B.V. 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213878/
https://ncbi.nlm.nih.gov/pubmed/34157321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2021.105115
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