CBIO-18. G-QUADRUPLEX STABILIZATION TARGETS ATRX-DEFICIENT HIGH-GRADE GLIOMA VIA INDUCTION OF p53-INDEPENDENT APOPTOSIS

Gliomas are the most common primary malignant brain tumor in adults and mutational inactivation of histone chaperone ATRX is a critical molecular marker in the classification of high-grade glioma (HGG). ATRX loss occurs with concurrent mutations in TP53 and IDH1/2, altering genome-wide accessibility...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Dharmaiah, Sharvari, Farooqi, Ahsan, Alvarez, Christian, Sharin, Vladislav, Irvin, David, Huse, Jason
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Cell Biology (Cell Cycle Regulation, DNA Repair/Modulation)
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650322/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.078
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