Synthesis and anti-HBV activity of carbocyclic nucleoside hybrids with salient features of entecavir and aristeromycin

Modified carbocyclic nucleosides (4a–g) constituting 7-deazapurine, 4′-methyl, exocyclic double bond and 2′,3′-hydroxy were synthesized. NOE and X-ray studies of 4c confirmed the α-configuration of 4′-methyl. The anti-HBV assay demonstrated 4e (IC(50) = 3.4 μM) without notable cytotoxicity (CC(50) =...

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Udgivet i:RSC Med Chem
Main Authors: Samunuri, Ramakrishnamraju, Toyama, Masaaki, Pallaka, Renuka Sivasankar, Neeladri, Seshubabu, Jha, Ashok Kumar, Baba, Masanori, Bal, Chandralata
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2020
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649829/
https://ncbi.nlm.nih.gov/pubmed/33479662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00059k
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