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Synthesis and anti-HBV activity of carbocyclic nucleoside hybrids with salient features of entecavir and aristeromycin
Modified carbocyclic nucleosides (4a–g) constituting 7-deazapurine, 4′-methyl, exocyclic double bond and 2′,3′-hydroxy were synthesized. NOE and X-ray studies of 4c confirmed the α-configuration of 4′-methyl. The anti-HBV assay demonstrated 4e (IC(50) = 3.4 μM) without notable cytotoxicity (CC(50) =...
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| Veröffentlicht in: | RSC Med Chem |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7649829/ https://ncbi.nlm.nih.gov/pubmed/33479662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00059k |
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