Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium

The genetic regulatory network controlling early fate choices during human blood cell development are not well understood. We used human pluripotent stem cell reporter lines to track the development of endothelial and haematopoietic populations in an in vitro model of human yolk-sac development. We...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Bruveris, Freya F., Ng, Elizabeth S., Leitoguinho, Ana Rita, Motazedian, Ali, Vlahos, Katerina, Sourris, Koula, Mayberry, Robyn, McDonald, Penelope, Azzola, Lisa, Davidson, Nadia M., Oshlack, Alicia, Stanley, Edouard G., Elefanty, Andrew G.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2020
Fag:
Human Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648599/
https://ncbi.nlm.nih.gov/pubmed/33028609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.193037
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