Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium

The genetic regulatory network controlling early fate choices during human blood cell development are not well understood. We used human pluripotent stem cell reporter lines to track the development of endothelial and haematopoietic populations in an in vitro model of human yolk-sac development. We...

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Detalles Bibliográficos
Publicado en:Development
Autores principales: Bruveris, Freya F., Ng, Elizabeth S., Leitoguinho, Ana Rita, Motazedian, Ali, Vlahos, Katerina, Sourris, Koula, Mayberry, Robyn, McDonald, Penelope, Azzola, Lisa, Davidson, Nadia M., Oshlack, Alicia, Stanley, Edouard G., Elefanty, Andrew G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2020
Materias:
Human Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648599/
https://ncbi.nlm.nih.gov/pubmed/33028609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.193037
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