Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner

Readministration of recombinant adeno-associated virus (rAAV) may be necessary to treat cystic fibrosis (CF) lung disease using gene therapy. However, little is known about rAAV-mediated immune responses in the lung. Here, we demonstrate the suitability of the ferret for testing AAV2.5T-mediated CFT...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Tang, Yinghua, Yan, Ziying, Lin, Shen, Huntemann, Eric D., Feng, Zehua, Park, Soo-Yeun, Sun, Xingshen, Yuen, Eric, Engelhardt, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648090/
https://ncbi.nlm.nih.gov/pubmed/33209961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.09.008
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