Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner

Readministration of recombinant adeno-associated virus (rAAV) may be necessary to treat cystic fibrosis (CF) lung disease using gene therapy. However, little is known about rAAV-mediated immune responses in the lung. Here, we demonstrate the suitability of the ferret for testing AAV2.5T-mediated CFT...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Tang, Yinghua, Yan, Ziying, Lin, Shen, Huntemann, Eric D., Feng, Zehua, Park, Soo-Yeun, Sun, Xingshen, Yuen, Eric, Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648090/
https://ncbi.nlm.nih.gov/pubmed/33209961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.09.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados