SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Folate metabolism enables cell growth by providing one-carbon (1C) units for nucleotide biosynthesis. The 1C units are carried by tetrahydrofolate (THF), whose production by the enzyme DHFR is targeted by the important anticancer drug methotrexate. 1C units come largely from serine catabolism by the...

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Publié dans:Leukemia
Auteurs principaux: García-Cañaveras, Juan C., Lancho, Olga, Ducker, Gregory S., Ghergurovich, Jonathan M., Xu, Xincheng, da Silva-Diz, Victoria, Minuzzo, Sonia, Indraccolo, Stefano, Kim, Hahn, Herranz, Daniel, Rabinowitz, Joshua D.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647950/
https://ncbi.nlm.nih.gov/pubmed/32382081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0845-6
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