PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia

The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resistance in T-ALL, and patients harboring mutations in the PI3K negative regulator PTEN may be at increas...

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發表在:Oncotarget
Main Authors: Silveira, André Bortolini, Laranjeira, Angelo Brunelli Albertoni, Rodrigues, Gisele Olinto Libanio, Leal, Paulo César, Cardoso, Bruno António, Barata, João Taborda, Yunes, Rosendo Augusto, Zanchin, Nilson Ivo Tonin, Brandalise, Sílvia Regina, Yunes, José Andrés
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2015
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537002/
https://ncbi.nlm.nih.gov/pubmed/25869207
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