Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

Notch1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage and subsequent activation, has been limited due to de...

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Vydáno v:Nat Commun
Hlavní autoři: Franciosa, Giulia, Smits, Jos G. A., Minuzzo, Sonia, Martinez-Val, Ana, Indraccolo, Stefano, Olsen, Jesper V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097059/
https://ncbi.nlm.nih.gov/pubmed/33947863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22787-9
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