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Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells

Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands. However, whether this highly dynamic physiologic process can be exploited to counteract dysregulated...

詳細記述

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書誌詳細
出版年:Oncogene
主要な著者: Pinazza, Marica, Ghisi, Margherita, Minuzzo, Sonia, Agnusdei, Valentina, Fossati, Gianluca, Ciminale, Vincenzo, Pezzè, Laura, Ciribilli, Yari, Pilotto, Giorgia, Venturoli, Carolina, Amadori, Alberto, Indraccolo, Stefano
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041259/
https://ncbi.nlm.nih.gov/pubmed/29643474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0234-z
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