Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells

Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands. However, whether this highly dynamic physiologic process can be exploited to counteract dysregulated...

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Udgivet i:Oncogene
Main Authors: Pinazza, Marica, Ghisi, Margherita, Minuzzo, Sonia, Agnusdei, Valentina, Fossati, Gianluca, Ciminale, Vincenzo, Pezzè, Laura, Ciribilli, Yari, Pilotto, Giorgia, Venturoli, Carolina, Amadori, Alberto, Indraccolo, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041259/
https://ncbi.nlm.nih.gov/pubmed/29643474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0234-z
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