Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

BACKGROUND: APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only a few APOBEC-associated driver hotspot mutat...

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Detalles Bibliográficos
Publicado en:Genome Med
Main Authors: Shi, Ming-Jun, Meng, Xiang-Yu, Fontugne, Jacqueline, Chen, Chun-Long, Radvanyi, François, Bernard-Pierrot, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646471/
https://ncbi.nlm.nih.gov/pubmed/32988402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00781-y
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