Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

BACKGROUND: APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only a few APOBEC-associated driver hotspot mutat...

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Bibliografische gegevens
Gepubliceerd in:Genome Med
Hoofdauteurs: Shi, Ming-Jun, Meng, Xiang-Yu, Fontugne, Jacqueline, Chen, Chun-Long, Radvanyi, François, Bernard-Pierrot, Isabelle
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646471/
https://ncbi.nlm.nih.gov/pubmed/32988402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00781-y
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