Poly(I:C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway

Emerging evidence suggests that Toll-like receptors (TLRs) ligands pretreatment may play a vital role in the progress of myocardial ischemia/reperfusion (I/R) injury. As the ligand of TLR3, polyinosinic-polycytidylic acid (poly(I:C)), a synthetic double-stranded RNA, whether its preconditioning can...

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Udgivet i:Signal Transduct Target Ther
Main Authors: Chen, Erya, Chen, Chan, Niu, Zhendong, Gan, Lu, Wang, Qiao, Li, Ming, Cai, XingWei, Gao, Rui, Katakam, Sruthi, Chen, Hai, Zhang, Shu, Zhou, Ronghua, Cheng, Xu, Qiu, Yanhua, Yu, Hai, Zhu, Tao, Liu, Jin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644758/
https://ncbi.nlm.nih.gov/pubmed/33154351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-00257-w
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