Clemastine Fumarate Protects Against Myocardial Ischemia Reperfusion Injury by Activating the TLR4/PI3K/Akt Signaling Pathway

Our pilot studies have shown that clemastine fumarate (CLE) can protect against myocardial ischemia-reperfusion injury (MIRI) through regulation of toll like receptor 4 (TLR4). However, the protective mechanism of CLE and related signaling pathways for MIRI remains unclear. The objective of this stu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Yuan, Xiaoxiao, Juan, Zhaodong, Zhang, Rui, Sun, Xiaotong, Yan, Ru, Yue, Feng, Huang, Yaru, Yu, Jiacheng, Xia, Xiaohui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025565/
https://ncbi.nlm.nih.gov/pubmed/32116705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00028
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